Science and Research 

Curcumin Science and Research

Disclaimer: Dr Tehs Turmeric Elixir”does not claim medicinal or therapeutic benefit. Information provided on this page is for educational purposes only and is in relation to Scientific research of Curcumin. Medical benefits listed are ingredient specific & general in nature. Studies below have been conducted using Curcumin  as an individual ingredient, not Dr Teh's Elixir specifically

It Really Is All About Inflammation!

Curcumin's physiological effects and actions are well known in the scientific community, and its mechanism of action is well understood on a microscopic level. It interacts with the human body in a myriad of ways, via many enzymes, proteins and genes. I will not try to “re invent the wheel” here and leave these basic facts up to your own research. 

 

HOW CURCUMIN INTERACTS WITH YOUR BODY:

The many ways Turmeric, and its main active ingredient CURCUMIN interacts with your bodies physiology https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025067/

BIOAVAILABILITY:                                                                                                                                     

Studies indicate that addition of black pepper (piper nigrum) increases bioavailabilty (absorption) of turmeric from 95% to 2000%

Here is the study indicating 2000%

https://www.thieme-connect.com/DOI/DOI?10.1055/s-2006-957450

DOSE AND SAFETY                                                                                                                                         

There are no recorded toxicities from turmeric ingestion.

Up to 12000mg of curcumin (approximately 600grams of raw turmeric) is safe for human consumption. http://www.greenmedinfo.com/article/safety-dosage-review-curcumin

http://www.greenmedinfo.com/article/curcumin-safe-humans-8000-mgday-when-take-mouth-3-months-and-has

WHY FRESH COLD PRESSED TURMERIC IS BEST

A meta analysis of studies indicating why fresh is best from the point of view of immune modulation and gene expression associated turmeric supplementation.

http://www.life-enhancement.com/magazine/article/2403-comparison-of-efficacy-of-turmeric-and-curcumin-in-immunological-measures-and-gene-regulation

CURCUMIN RESTRUCTURES YOUR CELL MEMBRANES                                                         

Many of the actions of turmeric listed are the result of Turmeric literally restructuring the cell walls of millions of cells in your body.

This article explaining how turmeric physically remodels your cell membranes. This results in decreased inflammation. Inflammation is disruption/ erosion of cell membranes in the cells  lining and making up your cardiovascular system.    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748423/

ANTI INFLAMMATORY ACTION - Pain Relief                                                                                                   

Modulation of inflammatory response is among the biological effects of curcumin. It is well documented that Turmeric is anti inflammatory.

Here is a review of such studies: http://www.altmedrev.com/publications/14/2/141.pdf

Curcumin’s anti-inflammatory potential is one of its most commonly researched aspects. It helps reduce inflammation by regulating inflammatory enzymes and proteins, specifically the cyclooxygenase (COX2) enzymes and cytokines. COX-2 enzyme inhibitors are the most frequently prescribed non-steroidal antiinflammatory drugs (NSAIDs/ ASPIRIN) for symptomatic relief of arthritic pain.

                                                                                                                                                       

Study showing decreased inflammatory mediators (TNF tumour necrosis factor) https://www.ncbi.nlm.nih.gov/pubmed/27025786

Post operative administration as anti inflammatory https://www.ncbi.nlm.nih.gov/pubmed/3546166

Post exercise muscle anti inflammatory effects http://www.greenmedinfo.com/article/curcumin-intake-has-some-beneficial-effects-recovery-eccentric-exercise

NEUROPROTECTIVE EFFECTS- Brain Health 

Due to its unique ability to cross the blood-brain barrier (BBB) (a protective mechanism that maintains a constant environment around the brain), curcumin is being studied extensively in many types of dementia.

Alzheimers and Dementia

Turmeric may be beneficial for alzheimers and Dementia, due to its ability to pass the BBB, its anti inflammatory, and anti oxidant effects, and subsequent increased blood flow: http://www.greenmedinfo.com/article/curcumin-appears-enhance-clearance-amyloid-beta-alzheimers-disease-patients

 

Stem Cell Repair

A less known active component of turmeric is tumerone has been seen to promote activation of the natural stem cells in our bodies. Also called endogenous neutral stem cells , they are critical in how the brain repairs itself and recovers function in neurodegenerative diseases. Though this is an animal study, it is included for relevance and possible areas of further research.

http://stemcellres.biomedcentral.com/articles/10.1186/scrt500

 

Neural Repair after Brain Trauma

http://www.greenmedinfo.com/article/curcumin-derivative-restores-membrane-homeostasis-disrupted-after-brain-trauma

 

Decreases inflammation after brain trauma -

http://www.greenmedinfo.com/article/administering-curcumin-may-alleviate-cerebral-inflammation-resultin

DEPRESSION- Mental Health                                                                                                                                                 

Positive effect of Turmeric on depression  and mental health.

https://www.ncbi.nlm.nih.gov/pubmed/26610378

Long term supplementation with turmeric may aid antidepressant medication 

https://www.ncbi.nlm.nih.gov/pubmed/26066335

Positive effect in major depressive disorder

http://www.greenmedinfo.com/node/105113

https://www.ncbi.nlm.nih.gov/pubmed/23832433

Indicates modes of action of antidepressant effect

http://www.greenmedinfo.com/article/curcumin-supplementation-influences-several-biomarkers-may-be-associated-its

 

Improved mood in depression

http://www.greenmedinfo.com/article/curcumin-was-significantly-more-effective-placebo-improving-several-mood

 

Curcumin and pepper effective in depressive disorders

http://www.greenmedinfo.com/article/curcuminoids-piperine-may-be-used-safe-and-effective-add-standard

Turmeric is a FREE RADICAL SCAVENGER (ANTI OXIDANT) By acting as a free radical scavenger curcumin can prevent oxidative DNA damage.

ORAL HEALTH

http://www.greenmedinfo.com/article/curcumin-comparable-chlorhexidine-anti-inflammatory-mouthwash-thus-it-can-be

CURCUMIN has potent immune modulator properties as it can activate the white blood cells (WBCs, or “police cells”) and natural killer cells that help in fighting abnormal cell growth and infections.

CHOLESTEROL

As antioxidants, curcuminoid compounds help maintain a healthy cardiovascular system by improving the viscosity of blood and reducing plaque formation in the arteries, both of which obstruct proper blood circulation. Recent studies show that curcumin may help maintain cholesterol levels by reducing low-density cholesterol (LDL) and triglyceride levels1.

http://www.greenmedinfo.com/article/curcumin-positively-modulates-blood-lipids-and-reduces-lipid-peroxidation

http://www.greenmedinfo.com/article/oral-curcumin-positively-modulates-blood-lipid-levels-and-lipid-peroxidation

http://www.greenmedinfo.com/article/administration-low-dose-curcumin-showed-trend-reduction-total-cholesterol

DIABETES AND OBESITY AND HYPERTENSION (high blood pressure) AND CARDIOVASCULAR DISEASE

These diseases all “go together” and are related due to their physiological causes, And the cause is inflammation.

OBESITY:  

Study showing positive effects in obese people

https://www.ncbi.nlm.nih.gov/pubmed/26592847

Study indicating the connection between obesity and systemic inflammation and immunoactivation, and reporting positive effects of curcumin. This is achieved by measuring blood levels of common inflammatory mediator molecules  https://www.hindawi.com/journals/tswj/2014/898361/

DIABETES:                                                                                                                                                        

Turmeric may be beneficial in the cardiovascular health of Diabetes patients

This study indicates this by measuring endothelial cell (blood vessels cells) dysfunction and inflammatory mediators (the proteins in blood that signal inflammation)  https://www.ncbi.nlm.nih.gov/pubmed/18588355

Increase in insulin secretion:

http://www.greenmedinfo.com/article/curcumin-may-increase-insulin-production-healthy-subjects

Decreased atherogenic risk in type 2 diabetes

http://www.greenmedinfo.com/article/reduction-atherogenic-risk-patients-type-2-diabetes-curcuminoid-extract

Prevention of type 2 diabetes  http://www.greenmedinfo.com/article/curcumin-extract-prevention-type-2-diabetes

CARDIOVASCULAR HEATLH:

General improvement of CVS health is noted due to anti oxidant, anti inflammatory and anti coagulant effects of Curcumin

 http://www.greenmedinfo.com/article/curcuminoids-reduce-frequency-acute-myocardial-infarction-after-coronary

https://www.ncbi.nlm.nih.gov/pubmed/22481014

OSTEOARTHRITIS:

This is due to its anti inflammatory effects, and also halted acute progression of disease as shown by decreased inflammatory mediators and genes associated with the inflammatory response

 

“(turmeric) inhibited joint inflammation and periarticular joint destruction in a dose-dependent manner. In vivo treatment prevented local activation of NF-κB and the subsequent expression of NF-κB–regulated genes mediating joint inflammation and destruction, including chemokines, cyclooxygenase 2, and RANKL. Consistent with these findings, inflammatory cell influx, joint levels of prostaglandin E2, and periarticular osteoclast formation were inhibited by turmeric extract treatment”

http://onlinelibrary.wiley.com/doi/10.1002/art.22180/full

https://www.ncbi.nlm.nih.gov/pubmed/27533649

https://www.ncbi.nlm.nih.gov/pubmed/21194249

Potential for cartilage regeneration

https://www.ncbi.nlm.nih.gov/pubmed/25352926

Potential in Rheumatoid Arthritis:                                   

http://www.greenmedinfo.com/article/curcumin-induces-programmed-cell-death-and-inhibits-proinflammatory

 

Safe and effective in treatment of Rheumatoid Arthritis

http://www.greenmedinfo.com/article/curcumin-treatment-safe-and-superior-drug-therapy-patients-active-ra

INFLAMMATORY BOWEL DISEASE-Chrons, IBS and Ulcerative colitis

Turmeric is beneficial in treatment of inflammatory bowel disease.

Helps maintain remission in ulcerative colitis

https://www.ncbi.nlm.nih.gov/pubmed/17101300

Chrons, ulcerative proctitis beneficial effect

http://www.greenmedinfo.com/article/curcumin-improves-ulcerative-proctitis-and-crohns-disease-patient-s

In conjunction with Salazine treatment

http://www.greenmedinfo.com/article/curcumin-may-be-safe-and-effective-therapy-maintenance-remission-quiescent-uc

Effective decreased inflammation of children with IBD

http://www.greenmedinfo.com/article/curcumin-suppresses-inflammation-mucosa-children-and-adults-inflammatory-bowel

LIVER DISEASE:

Oxidative stress plays a causative role in most liver disorders and models of hepatic injury, thus one of the mechanisms of action of turmeric on liver disease and damage. This study shows positive correlation with turmeric and repair of liver damage and disease                  http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2009.02086.x/full

Alcohol Induced Liver Diseasehttps://www.ncbi.nlm.nih.gov/pubmed/20080166

Biliary Pain (gall Bladder pain)- Gall bladder pain is often caused by dyskinesia (lack of contraction) Turmeric is effective in treatment of biliary pain:  https://www.ncbi.nlm.nih.gov/pubmed/10495621

Contractive effect on gall bladder

https://www.ncbi.nlm.nih.gov/pubmed/10102956

Dose rates for gall bladder emptying rates

https://www.ncbi.nlm.nih.gov/pubmed/12495265

ASTHMA:                                                                                                                                                            

Asthma is a chronic inflammatory disease of the airways. Regular turmeric may assist in treatment of asthma, in conjunction with regular treatment -http://www.greenmedinfo.com/article/curcumin-has-value-addon-therapy-patients-bronchial-asthma

PSORIASIS:                                                                                                                                                    

Turmeric may assist reduction of psoriasis taken orally

http://www.greenmedinfo.com/article/curcumin-suppresses-phosphorylase-kinase-activity-which-correlated-resolution

http://www.greenmedinfo.com/article/curcumin-was-demonstrated-be-effective-adjuvant-therapy-treatment-psoriasis

MULTIPLE SCLEROSIS:                                                                                                                         

Potential in MS treatment- http://www.greenmedinfo.com/article/review-curcumin-has-therapeutic-potential-multiple-sclerosis

PMS POTENTIAL DECREASE IN SYMPTOMS           

http://www.greenmedinfo.com/article/curcumin-attenuates-severity-premenstrual-syndrome-symptoms

PROTECTS AGAINST OXIDATIVE DAMAGE OF PESTICIDE EXPOSURE

 http://www.greenmedinfo.com/article/curcumin-protects-against-oxidative-damage-induced-pesticide-parathion

OTHER INFORMATIVE LINKS ON THE BENEFITS IF TURMERIC 

GOOD SCIENTIFIC GENERAL TURMERIC INFORMATION: http://articles.mercola.com/sites/articles/archive/2015/05/04/curcumin-turmeric-benefits.aspx

VERY BASIC ARTICLE OVERVIEW OF TURMERIC                   

 http://www.mnn.com/food/healthy-eating/stories/the-amazing-health-benefits-of-turmeric

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

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