Science and Research
Curcumin Science and Research
Disclaimer: Dr Tehs Turmeric Elixir”does not claim medicinal or therapeutic benefit. Information provided on this page is for educational purposes only and is in relation to Scientific research of Curcumin. Medical benefits listed are ingredient specific & general in nature. Studies below have been conducted using Curcumin as an individual ingredient, not Dr Teh's Elixir specifically.
It Really Is All About Inflammation!
Curcumin's physiological effects and actions are well known in the scientific community, and its mechanism of action is well understood on a microscopic level. It interacts with the human body in a myriad of ways, via many enzymes, proteins and genes. I will not try to “re invent the wheel” here and leave these basic facts up to your own research.
HOW CURCUMIN INTERACTS WITH YOUR BODY:
The many ways Turmeric, and its main active ingredient CURCUMIN interacts with your bodies physiology https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025067/
Studies indicate that addition of black pepper (piper nigrum) increases bioavailabilty (absorption) of turmeric from 95% to 2000%
Here is the study indicating 2000%
DOSE AND SAFETY
There are no recorded toxicities from turmeric ingestion.
Up to 12000mg of curcumin (approximately 600grams of raw turmeric) is safe for human consumption. http://www.greenmedinfo.com/article/safety-dosage-review-curcumin
WHY FRESH COLD PRESSED TURMERIC IS BEST
A meta analysis of studies indicating why fresh is best from the point of view of immune modulation and gene expression associated turmeric supplementation.
CURCUMIN RESTRUCTURES YOUR CELL MEMBRANES
Many of the actions of turmeric listed are the result of Turmeric literally restructuring the cell walls of millions of cells in your body.
This article explaining how turmeric physically remodels your cell membranes. This results in decreased inflammation. Inflammation is disruption/ erosion of cell membranes in the cells lining and making up your cardiovascular system. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748423/
ANTI INFLAMMATORY ACTION - Pain Relief
Modulation of inflammatory response is among the biological effects of curcumin. It is well documented that Turmeric is anti inflammatory.
Here is a review of such studies: http://www.altmedrev.com/publications/14/2/141.pdf
Curcumin’s anti-inflammatory potential is one of its most commonly researched aspects. It helps reduce inflammation by regulating inflammatory enzymes and proteins, specifically the cyclooxygenase (COX2) enzymes and cytokines. COX-2 enzyme inhibitors are the most frequently prescribed non-steroidal antiinflammatory drugs (NSAIDs/ ASPIRIN) for symptomatic relief of arthritic pain.
Study showing decreased inflammatory mediators (TNF tumour necrosis factor) https://www.ncbi.nlm.nih.gov/pubmed/27025786
Post operative administration as anti inflammatory https://www.ncbi.nlm.nih.gov/pubmed/3546166
Post exercise muscle anti inflammatory effects http://www.greenmedinfo.com/article/curcumin-intake-has-some-beneficial-effects-recovery-eccentric-exercise
NEUROPROTECTIVE EFFECTS- Brain Health
Due to its unique ability to cross the blood-brain barrier (BBB) (a protective mechanism that maintains a constant environment around the brain), curcumin is being studied extensively in many types of dementia.
Alzheimers and Dementia
Turmeric may be beneficial for alzheimers and Dementia, due to its ability to pass the BBB, its anti inflammatory, and anti oxidant effects, and subsequent increased blood flow: http://www.greenmedinfo.com/article/curcumin-appears-enhance-clearance-amyloid-beta-alzheimers-disease-patients
Stem Cell Repair
A less known active component of turmeric is tumerone has been seen to promote activation of the natural stem cells in our bodies. Also called endogenous neutral stem cells , they are critical in how the brain repairs itself and recovers function in neurodegenerative diseases. Though this is an animal study, it is included for relevance and possible areas of further research.
Neural Repair after Brain Trauma-
Decreases inflammation after brain trauma -
DEPRESSION- Mental Health
Positive effect of Turmeric on depression and mental health.
Long term supplementation with turmeric may aid antidepressant medication
Positive effect in major depressive disorder
Indicates modes of action of antidepressant effect
Improved mood in depression
Curcumin and pepper effective in depressive disorders
Turmeric is a FREE RADICAL SCAVENGER (ANTI OXIDANT) By acting as a free radical scavenger curcumin can prevent oxidative DNA damage.
CURCUMIN has potent immune modulator properties as it can activate the white blood cells (WBCs, or “police cells”) and natural killer cells that help in fighting abnormal cell growth and infections.
As antioxidants, curcuminoid compounds help maintain a healthy cardiovascular system by improving the viscosity of blood and reducing plaque formation in the arteries, both of which obstruct proper blood circulation. Recent studies show that curcumin may help maintain cholesterol levels by reducing low-density cholesterol (LDL) and triglyceride levels1.
DIABETES AND OBESITY AND HYPERTENSION (high blood pressure) AND CARDIOVASCULAR DISEASE
These diseases all “go together” and are related due to their physiological causes, And the cause is inflammation.
Study showing positive effects in obese people
Study indicating the connection between obesity and systemic inflammation and immunoactivation, and reporting positive effects of curcumin. This is achieved by measuring blood levels of common inflammatory mediator molecules https://www.hindawi.com/journals/tswj/2014/898361/
Turmeric may be beneficial in the cardiovascular health of Diabetes patients
This study indicates this by measuring endothelial cell (blood vessels cells) dysfunction and inflammatory mediators (the proteins in blood that signal inflammation) https://www.ncbi.nlm.nih.gov/pubmed/18588355
Increase in insulin secretion:
Decreased atherogenic risk in type 2 diabetes
Prevention of type 2 diabetes http://www.greenmedinfo.com/article/curcumin-extract-prevention-type-2-diabetes
General improvement of CVS health is noted due to anti oxidant, anti inflammatory and anti coagulant effects of Curcumin
This is due to its anti inflammatory effects, and also halted acute progression of disease as shown by decreased inflammatory mediators and genes associated with the inflammatory response
“(turmeric) inhibited joint inflammation and periarticular joint destruction in a dose-dependent manner. In vivo treatment prevented local activation of NF-κB and the subsequent expression of NF-κB–regulated genes mediating joint inflammation and destruction, including chemokines, cyclooxygenase 2, and RANKL. Consistent with these findings, inflammatory cell influx, joint levels of prostaglandin E2, and periarticular osteoclast formation were inhibited by turmeric extract treatment”
Potential for cartilage regeneration
Potential in Rheumatoid Arthritis:
Safe and effective in treatment of Rheumatoid Arthritis
INFLAMMATORY BOWEL DISEASE-Chrons, IBS and Ulcerative colitis
Turmeric is beneficial in treatment of inflammatory bowel disease.
Helps maintain remission in ulcerative colitis
Chrons, ulcerative proctitis beneficial effect
In conjunction with Salazine treatment
Effective decreased inflammation of children with IBD
Oxidative stress plays a causative role in most liver disorders and models of hepatic injury, thus one of the mechanisms of action of turmeric on liver disease and damage. This study shows positive correlation with turmeric and repair of liver damage and disease http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2009.02086.x/full
Alcohol Induced Liver Disease- https://www.ncbi.nlm.nih.gov/pubmed/20080166
Biliary Pain (gall Bladder pain)- Gall bladder pain is often caused by dyskinesia (lack of contraction) Turmeric is effective in treatment of biliary pain: https://www.ncbi.nlm.nih.gov/pubmed/10495621
Contractive effect on gall bladder
Dose rates for gall bladder emptying rates
Asthma is a chronic inflammatory disease of the airways. Regular turmeric may assist in treatment of asthma, in conjunction with regular treatment -http://www.greenmedinfo.com/article/curcumin-has-value-addon-therapy-patients-bronchial-asthma
Turmeric may assist reduction of psoriasis taken orally
Potential in MS treatment- http://www.greenmedinfo.com/article/review-curcumin-has-therapeutic-potential-multiple-sclerosis
PMS POTENTIAL DECREASE IN SYMPTOMS
PROTECTS AGAINST OXIDATIVE DAMAGE OF PESTICIDE EXPOSURE
OTHER INFORMATIVE LINKS ON THE BENEFITS IF TURMERIC
GOOD SCIENTIFIC GENERAL TURMERIC INFORMATION: http://articles.mercola.com/sites/articles/archive/2015/05/04/curcumin-turmeric-benefits.aspx
VERY BASIC ARTICLE OVERVIEW OF TURMERIC
This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.